IIT Gandhinagar: 15 Years of ExcellenceNews
Research

Chandrakumar Appayee

  1. Faculty
  2. Chemistry

  3. Chandrakumar Appayee

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Chandrakumar Appayee

Professor, Chemistry

  • BSc: University of Madras, 1997
  • MSc: Alagappa University, 2002
  • PhD: Indian Institute of Science, 2008

Email: a.chandra -AT- iitgn.ac.in

Website : https://appayee.people.iitgn.ac.in/

Office: 4/401 A
VOIP: 2462


  • Selected Publications

    1. Singh, S.; Kumar, R.; Dubey, N.; Appayee, C.* Synthesis and Application of Chiral cis-2,5-Disubstituted Pyrrolidine Organocatalysts” Chem. Commun. 2024, 60, 8768–8771. (Invited Article for the themed collection “2024 Pioneering Investigators”)

    2. Mehta, R.; Kumar, R.; Singh, S.; Appayee, C.* “Asymmetric Synthesis of α-Arylcyclohexenones Catalyzed by Diphenylprolinol Silyl Ether” J. Org. Chem. 2024, 89, 10892–10902.

    3. Kumar, R.; Maurya, V.; Avinash, A.; Appayee, C.* “Nonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes” J. Org. Chem. 2024, 89, 8586–8600.

    4. Kumar, R.; Singh, S.; Mehta, R.; Appayee, C.* “Polystyrene-Supported Aminocatalyst Derived from Diarylprolinol for Asymmetric α-Amination of Aldehydes” Eu. J. Org. Chem. 2023, 26, e202300147. (Invited Article for a special collection “Asymmetric Synthesis and Catalysis”)

    5. Maurya, V.; Kutwal, M. S.; Appayee, C.* “Direct Catalytic Asymmetric Synthesis of Disubstituted 4-Oxocyclohexanecarbaldehydes from Acetone and Cinnamaldehyde Derivatives” Org. Lett. 2021, 23, 1566–1571.

    6. Sarkale, A. M.; Appayee, C.* “Stereodivergent Synthesis of 1-Hydroxymethylpyrrolizidine Alkaloids” Org. Lett. 2020, 22, 4355-4359.

  • Work Experience

    • Professor, Indian Institute of Technology Gandhinagar (Nov 2024 to Present)
    • Associate Professor, Indian Institute of Technology Gandhinagar (Feb 2020 - Nov 2024)
    • Assistant Professor, Indian Institute of Technology Gandhinagar (Dec 2013 - Feb 2020)
    • Postdoctoral Research Scientist, Columbia University, New York, (Jun 2012 - Dec 2013)
    • Postdoctoral Research Associate, Brooklyn College and the City University of New York, (July 2009 - Jun 2012)
    • Postdoctoral Research Associate, University of Miami, Florida, (July 2008 - Jun 2009)

  • Patents

    1. Appayee, C.; Kumar, R.; Avinash, A. “A chiral non-silyl bicyclic secondary amine catalyst for asymmetric transfer hydrogenation”. Application No. IN202421075230, dated October 4, 2024.

    2. Appayee, C.; Singh, S.; Kumar, R.; Dubey, N. N. “cis-5-Substituted alkyl diarylprolinol silyl ether organocatalysts and a process of its preparation”. Application No. IN202321077734, dated November 15, 2023.

    3. Appayee, C.; Padmaja, V. M. D.;  Kutwal, M. S. “Photochromic organic compounds and a process for preparation thereof”. Application No. IN202021012829, dated March 24, 2020.  

    4. Appayee, C.; Padmaja, V. M. D. “Photochromic organic compounds and a process for preparation thereof”. Application No. IN202021012831, dated March 24, 2020, issued as Patent No. 498888, dated January 12, 2024.  

    5. Appayee, C.; Sarkale, A. M. “Method for the asymmetric synthesis of (S)-paraconic acid”. Application No. IN201721019540, dated June 3, 2017, issued as Patent No. 391941, dated March 14, 2022.

Research Interests

  • ● Asymmetric organocatalysis
  • ● Development of novel organocatalysts
  • ● Asymmetric synthesis of bio-active molecules
  • ● Total synthesis of natural products

Complete List of Publications