IIT Gandhinagar: 10 Years of ExcellenceNews

Sharad Gupta

  1. Faculty
  2. Biological Engineering

  3. Sharad Gupta

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Sharad Gupta

Associate Professor, Biological Engineering

  • MSc(Integrated, 5yr.): IIT Kanpur, 2003
  • PhD: University of Pittsburgh, 2009

Email: sharad -AT- iitgn.ac.in

Website : http://sharad.people.iitgn.ac.in/

Office: 4/314 A
VOIP: 2440


  • Work Experience

    • Associate Professor, Indian Institute of Technology Gandhinagar (Feb 2019 to present)
    • Assistant Professor, Indian Institute of Technology Gandhinagar (July 2012 to Jan 2019)
    • Post Doctoral Fellow, Department of Chemical and Biomolecular Engineering, University of Delaware (Aug 2010 - June 2012)
    • Post Doctoral Researcher, Department of Chemistry, Temple University (Sept 2009-July 2010)

  • Selected Publications

    1. Krishnakumar, Guru V. and Gupta, Sharad, "Simplified method to obtain enhanced expression of Tau protein from E. coli and one-step purification by direct boiling", Preparative Biochemistry and Biotechnology, DOI: 10.1080/10826068.2016.1275012, 2017.

    2. Mani, Vedamalai; Krishnakumar, Guru V.; Gupta, Sharad; Mori, Shigeki and Gupta, Iti, "Synthesis and characterization of styryl-BODIPY derivatives for monitoring in vitro Tau aggregation", Sensors and Actuators B: Chemical, DOI: 10.1016/j.snb.2016.12.104, 2017.

    3. Modak, S.; Guru KrishnaKumar, V.; Gupta, S.; and Thareja, P.; "Influence of Phosphorylation on the Foamability and Stability of Bovine Serum Albumin and Citrus Peel Pectin Mixed Foams", Journal of Dispersion Science and Technology, 2016.

    4. Ralhan, K.; Guru Krishna Kumar, V.; Gupta. S. "Piperazine and DBU: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis." RSC Advances,2015, 5, 104417-104425. DOI: 10.1039/C5RA23441G.

    5. Morozova, O. A.; Gupta, S.; Colby, D. W. "Prefibrillar Huntington oligomers isolated from HD brain potentially seed amyloid formation" FEBS letters, 589(15):1897-903, 2015. doi: 10.1016/j.febslet.2015.05. * Equal contribution.

    6. Gupta, S.; Jie, S.; Colby, D. W. "Protein misfolding detected early in the pathogenesis of a transgenic mouse model of Huntington's disease using an amyloid seeding assay." J. Biol. Chem. 2012, 287, 9982-9989.

Research Interests

  • ● Protein aggregation and their role in neurodegenerative disorders
  • ● Role of post translational modifications on protein aggregation and toxicity
  • ● Peptides as molecular probes / therapeutics in Alzheimer's disease and related disorders
  • ● Role of proteomics in understanding the effect of disease modifying therapies
  • ● Difficult peptide synthesis and novel scaffolds